KLHL36 protein (Homo sapiens) - STRING network view

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KLHL36

kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (616 aa)

Predicted Functional Partners:

KIAA1609

0.584

ATP2C2

0.567

TAF1C

0.510

USP10

0.509

HSBP1

0.470

OSGIN1

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2C2	KLHL36	ENSP00000262429	ENSP00000456743	ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity)	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.567
HSBP1	KLHL36	ENSP00000392896	ENSP00000456743	heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.470
KIAA1609	KLHL36	ENSP00000343635	ENSP00000456743	KIAA1609	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.584
KLHL36	ATP2C2	ENSP00000456743	ENSP00000262429	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity)	0.567
KLHL36	HSBP1	ENSP00000456743	ENSP00000392896	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process	0.470
KLHL36	KIAA1609	ENSP00000456743	ENSP00000343635	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	KIAA1609	0.584
KLHL36	OSGIN1	ENSP00000456743	ENSP00000355374	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	oxidative stress induced growth inhibitor 1; Regulates the differentiation and proliferation of normal cells through the regulation of cell death	0.457
KLHL36	TAF1C	ENSP00000456743	ENSP00000367802	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene prom [...]	0.510
KLHL36	USP10	ENSP00000456743	ENSP00000219473	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...]	0.509
OSGIN1	KLHL36	ENSP00000355374	ENSP00000456743	oxidative stress induced growth inhibitor 1; Regulates the differentiation and proliferation of normal cells through the regulation of cell death	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.457
TAF1C	KLHL36	ENSP00000367802	ENSP00000456743	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene prom [...]	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.510
USP10	KLHL36	ENSP00000219473	ENSP00000456743	ubiquitin specific peptidase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability- in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key [...]	kelch-like 36 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.509

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