ENSG00000254995 protein (Homo sapiens)

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protein of unknown 3D structure

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Score

ENSG00000254995

STX16-NPEPL1 readthrough (non-protein coding) (382 aa)

Predicted Functional Partners:

STX10

0.988

STX6

0.988

VTI1A

0.988

VTI1B

0.976

VAMP4

0.958

STX8

0.944

VPS45

0.926

YKT6

0.926

SCFD1

0.855

VPS54

0.842

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000254995	SCFD1	ENSP00000457522	ENSP00000390783	STX16-NPEPL1 readthrough (non-protein coding)	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	0.855
ENSG00000254995	STX10	ENSP00000457522	ENSP00000466298	STX16-NPEPL1 readthrough (non-protein coding)	syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network	0.988
ENSG00000254995	STX6	ENSP00000457522	ENSP00000258301	STX16-NPEPL1 readthrough (non-protein coding)	syntaxin 6; Involved in intracellular vesicle trafficking	0.988
ENSG00000254995	STX8	ENSP00000457522	ENSP00000305255	STX16-NPEPL1 readthrough (non-protein coding)	syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER	0.944
ENSG00000254995	VAMP4	ENSP00000457522	ENSP00000236192	STX16-NPEPL1 readthrough (non-protein coding)	vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule	0.958
ENSG00000254995	VPS45	ENSP00000457522	ENSP00000358126	STX16-NPEPL1 readthrough (non-protein coding)	vacuolar protein sorting 45 homolog (S. cerevisiae); May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network	0.926
ENSG00000254995	VPS54	ENSP00000457522	ENSP00000272322	STX16-NPEPL1 readthrough (non-protein coding)	vacuolar protein sorting 54 homolog (S. cerevisiae); May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD	0.842
ENSG00000254995	VTI1A	ENSP00000457522	ENSP00000376792	STX16-NPEPL1 readthrough (non-protein coding)	vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...]	0.988
ENSG00000254995	VTI1B	ENSP00000457522	ENSP00000450731	STX16-NPEPL1 readthrough (non-protein coding)	vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence	0.976
ENSG00000254995	YKT6	ENSP00000457522	ENSP00000223369	STX16-NPEPL1 readthrough (non-protein coding)	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.926
SCFD1	ENSG00000254995	ENSP00000390783	ENSP00000457522	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	STX16-NPEPL1 readthrough (non-protein coding)	0.855
SCFD1	STX10	ENSP00000390783	ENSP00000466298	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network	0.539
SCFD1	STX6	ENSP00000390783	ENSP00000258301	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	syntaxin 6; Involved in intracellular vesicle trafficking	0.639
SCFD1	STX8	ENSP00000390783	ENSP00000305255	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER	0.574
SCFD1	VAMP4	ENSP00000390783	ENSP00000236192	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule	0.692
SCFD1	VTI1A	ENSP00000390783	ENSP00000376792	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...]	0.911
SCFD1	VTI1B	ENSP00000390783	ENSP00000450731	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence	0.940
SCFD1	YKT6	ENSP00000390783	ENSP00000223369	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.983
STX10	ENSG00000254995	ENSP00000466298	ENSP00000457522	syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network	STX16-NPEPL1 readthrough (non-protein coding)	0.988
STX10	SCFD1	ENSP00000466298	ENSP00000390783	syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network	sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity)	0.539

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