| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS2 | METTL4 | ENSP00000264276 | ENSP00000458290 | amyotrophic lateral sclerosis 2 (juvenile); May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity) | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.549 |
| CLUL1 | LPIN2 | ENSP00000341128 | ENSP00000261596 | clusterin-like 1 (retinal) | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | 0.560 |
| CLUL1 | METTL4 | ENSP00000341128 | ENSP00000458290 | clusterin-like 1 (retinal) | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.510 |
| FAM179A | METTL4 | ENSP00000368876 | ENSP00000458290 | family with sequence similarity 179, member A | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.538 |
| LPIN2 | CLUL1 | ENSP00000261596 | ENSP00000341128 | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | clusterin-like 1 (retinal) | 0.560 |
| LPIN2 | METTL4 | ENSP00000261596 | ENSP00000458290 | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.476 |
| LPIN2 | SMCHD1 | ENSP00000261596 | ENSP00000326603 | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | structural maintenance of chromosomes flexible hinge domain containing 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.712 |
| METTL14 | METTL3 | ENSP00000373474 | ENSP00000298717 | methyltransferase like 14; Probable methyltransferase (By similarity) | methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation | 0.989 |
| METTL14 | METTL4 | ENSP00000373474 | ENSP00000458290 | methyltransferase like 14; Probable methyltransferase (By similarity) | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.910 |
| METTL3 | METTL14 | ENSP00000298717 | ENSP00000373474 | methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation | methyltransferase like 14; Probable methyltransferase (By similarity) | 0.989 |
| METTL3 | METTL4 | ENSP00000298717 | ENSP00000458290 | methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation | methyltransferase like 4; Probable methyltransferase (By similarity) | 0.910 |
| METTL4 | ALS2 | ENSP00000458290 | ENSP00000264276 | methyltransferase like 4; Probable methyltransferase (By similarity) | amyotrophic lateral sclerosis 2 (juvenile); May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity) | 0.549 |
| METTL4 | CLUL1 | ENSP00000458290 | ENSP00000341128 | methyltransferase like 4; Probable methyltransferase (By similarity) | clusterin-like 1 (retinal) | 0.510 |
| METTL4 | FAM179A | ENSP00000458290 | ENSP00000368876 | methyltransferase like 4; Probable methyltransferase (By similarity) | family with sequence similarity 179, member A | 0.538 |
| METTL4 | LPIN2 | ENSP00000458290 | ENSP00000261596 | methyltransferase like 4; Probable methyltransferase (By similarity) | lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) | 0.476 |
| METTL4 | METTL14 | ENSP00000458290 | ENSP00000373474 | methyltransferase like 4; Probable methyltransferase (By similarity) | methyltransferase like 14; Probable methyltransferase (By similarity) | 0.910 |
| METTL4 | METTL3 | ENSP00000458290 | ENSP00000298717 | methyltransferase like 4; Probable methyltransferase (By similarity) | methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation | 0.910 |
| METTL4 | MRPS18B | ENSP00000458290 | ENSP00000259873 | methyltransferase like 4; Probable methyltransferase (By similarity) | mitochondrial ribosomal protein S18B | 0.594 |
| METTL4 | RPN2 | ENSP00000458290 | ENSP00000237530 | methyltransferase like 4; Probable methyltransferase (By similarity) | ribophorin II; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | 0.543 |
| METTL4 | SMCHD1 | ENSP00000458290 | ENSP00000326603 | methyltransferase like 4; Probable methyltransferase (By similarity) | structural maintenance of chromosomes flexible hinge domain containing 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells | 0.418 |
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