node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANPEP | GCLC | ENSP00000300060 | ENSP00000229416 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | glutamate-cysteine ligase, catalytic subunit | 0.916 |
ANPEP | GGT6 | ENSP00000300060 | ENSP00000458307 | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.916 |
GCLC | ANPEP | ENSP00000229416 | ENSP00000300060 | glutamate-cysteine ligase, catalytic subunit | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | 0.916 |
GCLC | GGT6 | ENSP00000229416 | ENSP00000458307 | glutamate-cysteine ligase, catalytic subunit | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.926 |
GCLC | GPX1 | ENSP00000229416 | ENSP00000407375 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.716 |
GCLC | GPX2 | ENSP00000229416 | ENSP00000374265 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | 0.718 |
GCLC | GPX3 | ENSP00000229416 | ENSP00000373477 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | 0.549 |
GCLC | GPX4 | ENSP00000229416 | ENSP00000346103 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) | 0.533 |
GCLC | GPX6 | ENSP00000229416 | ENSP00000354581 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 6 (olfactory) | 0.422 |
GCLC | GPX7 | ENSP00000229416 | ENSP00000354677 | glutamate-cysteine ligase, catalytic subunit | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.488 |
GCLC | GSR | ENSP00000229416 | ENSP00000221130 | glutamate-cysteine ligase, catalytic subunit | glutathione reductase; Maintains high levels of reduced glutathione in the cytosol | 0.838 |
GGT6 | ANPEP | ENSP00000458307 | ENSP00000300060 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | alanyl (membrane) aminopeptidase; Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrad [...] | 0.916 |
GGT6 | GCLC | ENSP00000458307 | ENSP00000229416 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutamate-cysteine ligase, catalytic subunit | 0.926 |
GGT6 | GPX1 | ENSP00000458307 | ENSP00000407375 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown | 0.915 |
GGT6 | GPX2 | ENSP00000458307 | ENSP00000374265 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | 0.932 |
GGT6 | GPX3 | ENSP00000458307 | ENSP00000373477 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | 0.915 |
GGT6 | GPX4 | ENSP00000458307 | ENSP00000346103 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) | 0.923 |
GGT6 | GPX6 | ENSP00000458307 | ENSP00000354581 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 6 (olfactory) | 0.915 |
GGT6 | GPX7 | ENSP00000458307 | ENSP00000354677 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks | 0.915 |
GGT6 | GPX8 | ENSP00000458307 | ENSP00000423822 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | glutathione peroxidase 8 (putative) | 0.915 |