node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKFY1 | ARRB2 | ENSP00000459775 | ENSP00000269260 | ankyrin repeat and FYVE domain containing 1 | arrestin, beta 2 | 0.755 |
ANKFY1 | CTNNA2 | ENSP00000459775 | ENSP00000418191 | ankyrin repeat and FYVE domain containing 1 | catenin (cadherin-associated protein), alpha 2 | 0.707 |
ANKFY1 | CTNNA3 | ENSP00000459775 | ENSP00000362849 | ankyrin repeat and FYVE domain containing 1 | catenin (cadherin-associated protein), alpha 3; May be involved in formation of stretch-resistant cell- cell adhesion complexes | 0.707 |
ANKFY1 | GBAS | ENSP00000459775 | ENSP00000313050 | ankyrin repeat and FYVE domain containing 1 | glioblastoma amplified sequence | 0.738 |
ANKFY1 | KIF1C | ENSP00000459775 | ENSP00000320821 | ankyrin repeat and FYVE domain containing 1 | kinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility | 0.877 |
ANKFY1 | RAD21 | ENSP00000459775 | ENSP00000297338 | ankyrin repeat and FYVE domain containing 1 | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.726 |
ANKFY1 | RAD21L1 | ENSP00000459775 | ENSP00000386414 | ankyrin repeat and FYVE domain containing 1 | RAD21-like 1 (S. pombe); Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity) | 0.726 |
ANKFY1 | REC8 | ENSP00000459775 | ENSP00000308699 | ankyrin repeat and FYVE domain containing 1 | REC8 homolog (yeast); Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity) | 0.726 |
ANKFY1 | UBC | ENSP00000459775 | ENSP00000344818 | ankyrin repeat and FYVE domain containing 1 | ubiquitin C | 0.908 |
ANKFY1 | USPL1 | ENSP00000459775 | ENSP00000255304 | ankyrin repeat and FYVE domain containing 1 | ubiquitin specific peptidase like 1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation | 0.740 |
ARRB2 | ANKFY1 | ENSP00000269260 | ENSP00000459775 | arrestin, beta 2 | ankyrin repeat and FYVE domain containing 1 | 0.755 |
ARRB2 | KIF1C | ENSP00000269260 | ENSP00000320821 | arrestin, beta 2 | kinesin family member 1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility | 0.659 |
ARRB2 | UBC | ENSP00000269260 | ENSP00000344818 | arrestin, beta 2 | ubiquitin C | 0.999 |
CTNNA2 | ANKFY1 | ENSP00000418191 | ENSP00000459775 | catenin (cadherin-associated protein), alpha 2 | ankyrin repeat and FYVE domain containing 1 | 0.707 |
CTNNA2 | RAD21 | ENSP00000418191 | ENSP00000297338 | catenin (cadherin-associated protein), alpha 2 | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.723 |
CTNNA2 | UBC | ENSP00000418191 | ENSP00000344818 | catenin (cadherin-associated protein), alpha 2 | ubiquitin C | 0.892 |
CTNNA3 | ANKFY1 | ENSP00000362849 | ENSP00000459775 | catenin (cadherin-associated protein), alpha 3; May be involved in formation of stretch-resistant cell- cell adhesion complexes | ankyrin repeat and FYVE domain containing 1 | 0.707 |
CTNNA3 | RAD21 | ENSP00000362849 | ENSP00000297338 | catenin (cadherin-associated protein), alpha 3; May be involved in formation of stretch-resistant cell- cell adhesion complexes | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.723 |
GBAS | ANKFY1 | ENSP00000313050 | ENSP00000459775 | glioblastoma amplified sequence | ankyrin repeat and FYVE domain containing 1 | 0.738 |
GBAS | UBC | ENSP00000313050 | ENSP00000344818 | glioblastoma amplified sequence | ubiquitin C | 0.483 |