Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
BBS9 BBS9 IFT80 IFT80 CLU CLU ENSG00000248710 ENSG00000248710 CLUAP1 CLUAP1 IFT52 IFT52 TTC26 TTC26 WDR35 WDR35 IFT57 IFT57 IFT172 IFT172 HYDIN HYDIN
"CLUAP1" - clusterin associated protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLUAP1clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) (413 aa)    
Predicted Functional Partners:
IFT80
intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)
            score_image   0.759
HYDIN
HYDIN, axonemal central pair apparatus protein (1017 aa)
            score_image   0.724
ENSG00000248710
Uncharacterized protein (948 aa)
            score_image   0.720
IFT172
intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) (1749 aa)
            score_image   0.706
IFT57
intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (429 aa)
            score_image   0.687
TTC26
tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) (554 aa)
            score_image   0.679
IFT52
intraflagellar transport 52 homolog (Chlamydomonas) (437 aa)
            score_image   0.678
CLU
clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] (449 aa)
        score_image   score_image   0.645
BBS9
Bardet-Biedl syndrome 9 (887 aa)
            score_image   0.631
WDR35
WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis (1181 aa)
            score_image   0.624
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (25%)