node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BBS9 | CLUAP1 | ENSP00000242067 | ENSP00000460850 | Bardet-Biedl syndrome 9 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | 0.631 |
BBS9 | ENSG00000248710 | ENSP00000242067 | ENSP00000456272 | Bardet-Biedl syndrome 9 | Uncharacterized protein | 0.507 |
BBS9 | IFT80 | ENSP00000242067 | ENSP00000312778 | Bardet-Biedl syndrome 9 | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.513 |
BBS9 | TTC26 | ENSP00000242067 | ENSP00000419279 | Bardet-Biedl syndrome 9 | tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) | 0.493 |
CLU | CLUAP1 | ENSP00000315130 | ENSP00000460850 | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | 0.645 |
CLUAP1 | BBS9 | ENSP00000460850 | ENSP00000242067 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | Bardet-Biedl syndrome 9 | 0.631 |
CLUAP1 | CLU | ENSP00000460850 | ENSP00000315130 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosom [...] | 0.645 |
CLUAP1 | ENSG00000248710 | ENSP00000460850 | ENSP00000456272 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | Uncharacterized protein | 0.720 |
CLUAP1 | HYDIN | ENSP00000460850 | ENSP00000314736 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | HYDIN, axonemal central pair apparatus protein | 0.724 |
CLUAP1 | IFT172 | ENSP00000460850 | ENSP00000260570 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) | 0.706 |
CLUAP1 | IFT52 | ENSP00000460850 | ENSP00000362121 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | intraflagellar transport 52 homolog (Chlamydomonas) | 0.678 |
CLUAP1 | IFT57 | ENSP00000460850 | ENSP00000264538 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.687 |
CLUAP1 | IFT80 | ENSP00000460850 | ENSP00000312778 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.759 |
CLUAP1 | TTC26 | ENSP00000460850 | ENSP00000419279 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) | 0.679 |
CLUAP1 | WDR35 | ENSP00000460850 | ENSP00000314444 | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis | 0.624 |
ENSG00000248710 | BBS9 | ENSP00000456272 | ENSP00000242067 | Uncharacterized protein | Bardet-Biedl syndrome 9 | 0.507 |
ENSG00000248710 | CLUAP1 | ENSP00000456272 | ENSP00000460850 | Uncharacterized protein | clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity) | 0.720 |
ENSG00000248710 | IFT52 | ENSP00000456272 | ENSP00000362121 | Uncharacterized protein | intraflagellar transport 52 homolog (Chlamydomonas) | 0.848 |
ENSG00000248710 | IFT57 | ENSP00000456272 | ENSP00000264538 | Uncharacterized protein | intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear | 0.841 |
ENSG00000248710 | WDR35 | ENSP00000456272 | ENSP00000314444 | Uncharacterized protein | WD repeat domain 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis | 0.592 |