Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C19orf47 | chromosome 19 open reading frame 47 (422 aa) | ||||||||||||
Predicted Functional Partners:
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 | TTC9B | tetratricopeptide repeat domain 9B (239 aa) |
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0.757 | ||||||||||
 | ZNF546 | zinc finger protein 546; May be involved in transcriptional regulation (836 aa) |
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0.722 | ||||||||||
 | ZNF780B | zinc finger protein 780B; May be involved in transcriptional regulation (By similarity) (833 aa) |
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0.643 | ||||||||||
 | NTM | neurotrimin; Neural cell adhesion molecule (355 aa) |
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0.603 | ||||||||||
 | SAMD4B | sterile alpha motif domain containing 4B; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (694 aa) |
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0.583 | ||||||||||
 | PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as [...] (552 aa) |
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0.573 | ||||||||||
 | LRFN1 | leucine rich repeat and fibronectin type III domain containing 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity) (771 aa) |
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0.509 | ||||||||||
 | LGALS14 | lectin, galactoside-binding, soluble, 14 (168 aa) |
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0.503 | ||||||||||
 | PRR13 | proline rich 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis (148 aa) |
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0.499 | ||||||||||
 | CNTD2 | cyclin N-terminal domain containing 2 (307 aa) |
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0.472 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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