ENSG00000263620 protein (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

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Score

ENSG00000263620

Uncharacterized protein (121 aa)

Predicted Functional Partners:

STX4

0.998

STX1B

0.998

SNAP23

0.993

STX2

0.989

STX3

0.988

STXBP1

0.984

STX1A

0.979

VTI1B

0.936

SNAP25

0.927

KCNB1

0.925

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSG00000263620	KCNB1	ENSP00000464383	ENSP00000360806	Uncharacterized protein	potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient	0.925
ENSG00000263620	SNAP23	ENSP00000464383	ENSP00000249647	Uncharacterized protein	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	0.993
ENSG00000263620	SNAP25	ENSP00000464383	ENSP00000254976	Uncharacterized protein	synaptosomal-associated protein, 25kDa	0.927
ENSG00000263620	STX1A	ENSP00000464383	ENSP00000222812	Uncharacterized protein	syntaxin 1A (brain)	0.979
ENSG00000263620	STX1B	ENSP00000464383	ENSP00000215095	Uncharacterized protein	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.998
ENSG00000263620	STX2	ENSP00000464383	ENSP00000376178	Uncharacterized protein	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.989
ENSG00000263620	STX3	ENSP00000464383	ENSP00000338562	Uncharacterized protein	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.988
ENSG00000263620	STX4	ENSP00000464383	ENSP00000317714	Uncharacterized protein	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.998
ENSG00000263620	STXBP1	ENSP00000464383	ENSP00000362399	Uncharacterized protein	syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions	0.984
ENSG00000263620	VTI1B	ENSP00000464383	ENSP00000450731	Uncharacterized protein	vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence	0.936
KCNB1	ENSG00000263620	ENSP00000360806	ENSP00000464383	potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient	Uncharacterized protein	0.925
KCNB1	SNAP25	ENSP00000360806	ENSP00000254976	potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient	synaptosomal-associated protein, 25kDa	0.576
KCNB1	STX1A	ENSP00000360806	ENSP00000222812	potassium voltage-gated channel, Shab-related subfamily, member 1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient	syntaxin 1A (brain)	0.576
SNAP23	ENSG00000263620	ENSP00000249647	ENSP00000464383	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	Uncharacterized protein	0.993
SNAP23	STX1A	ENSP00000249647	ENSP00000222812	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 1A (brain)	0.887
SNAP23	STX1B	ENSP00000249647	ENSP00000215095	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.992
SNAP23	STX2	ENSP00000249647	ENSP00000376178	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.999
SNAP23	STX3	ENSP00000249647	ENSP00000338562	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.999
SNAP23	STX4	ENSP00000249647	ENSP00000317714	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.999
SNAP23	STXBP1	ENSP00000249647	ENSP00000362399	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions	0.885

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