node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC6 | POU5F2 | ENSP00000378735 | ENSP00000464890 | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.550 |
GAK | POU5F2 | ENSP00000314499 | ENSP00000464890 | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.563 |
GPR125 | POU5F2 | ENSP00000334952 | ENSP00000464890 | G protein-coupled receptor 125; Orphan receptor | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.577 |
POU5F2 | DNAJC6 | ENSP00000464890 | ENSP00000378735 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | DnaJ (Hsp40) homolog, subfamily C, member 6; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles (By similarity) | 0.550 |
POU5F2 | GAK | ENSP00000464890 | ENSP00000314499 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.563 |
POU5F2 | GPR125 | ENSP00000464890 | ENSP00000334952 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | G protein-coupled receptor 125; Orphan receptor | 0.577 |
POU5F2 | PTEN | ENSP00000464890 | ENSP00000361021 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.550 |
POU5F2 | SLC3A1 | ENSP00000464890 | ENSP00000260649 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | 0.581 |
POU5F2 | SLC7A14 | ENSP00000464890 | ENSP00000231706 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | solute carrier family 7 (orphan transporter), member 14 | 0.578 |
POU5F2 | TENC1 | ENSP00000464890 | ENSP00000319756 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | tensin like C1 domain containing phosphatase (tensin 2) | 0.562 |
POU5F2 | TNS1 | ENSP00000464890 | ENSP00000171887 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton | 0.562 |
POU5F2 | TNS3 | ENSP00000464890 | ENSP00000312143 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity) | 0.562 |
POU5F2 | TPTE2 | ENSP00000464890 | ENSP00000372437 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 | 0.550 |
PTEN | POU5F2 | ENSP00000361021 | ENSP00000464890 | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.550 |
SLC3A1 | POU5F2 | ENSP00000260649 | ENSP00000464890 | solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.581 |
SLC7A14 | POU5F2 | ENSP00000231706 | ENSP00000464890 | solute carrier family 7 (orphan transporter), member 14 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.578 |
TENC1 | POU5F2 | ENSP00000319756 | ENSP00000464890 | tensin like C1 domain containing phosphatase (tensin 2) | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.562 |
TNS1 | POU5F2 | ENSP00000171887 | ENSP00000464890 | tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.562 |
TNS3 | POU5F2 | ENSP00000312143 | ENSP00000464890 | tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity) | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.562 |
TPTE2 | POU5F2 | ENSP00000372437 | ENSP00000464890 | transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 | POU domain class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5’-ATGTTAAT-3’). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity) | 0.550 |