C18orf21 protein (Homo sapiens) - STRING network view

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C18orf21

chromosome 18 open reading frame 21 (220 aa)

Predicted Functional Partners:

ANKRD52

0.676

RPRD1A

0.659

NABP2

0.653

MOCOS

0.646

STK17B

0.582

GALNT1

0.514

ISG20L2

0.501

STK17A

0.435

RASSF2

0.402

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD52	C18orf21	ENSP00000267116	ENSP00000465517	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	chromosome 18 open reading frame 21	0.676
ANKRD52	MOCOS	ENSP00000267116	ENSP00000261326	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime	0.462
ANKRD52	NABP2	ENSP00000267116	ENSP00000267023	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	0.608
ANKRD52	RASSF2	ENSP00000267116	ENSP00000368684	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation	0.424
ANKRD52	RPRD1A	ENSP00000267116	ENSP00000349955	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle	0.638
ANKRD52	STK17A	ENSP00000267116	ENSP00000319192	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species	0.400
ANKRD52	STK17B	ENSP00000267116	ENSP00000263955	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis	0.437
C18orf21	ANKRD52	ENSP00000465517	ENSP00000267116	chromosome 18 open reading frame 21	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	0.676
C18orf21	GALNT1	ENSP00000465517	ENSP00000269195	chromosome 18 open reading frame 21	UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7	0.514
C18orf21	ISG20L2	ENSP00000465517	ENSP00000323424	chromosome 18 open reading frame 21	interferon stimulated exonuclease gene 20kDa-like 2; 3’-> 5’-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3’-end containing a free hydroxyl group	0.501
C18orf21	MOCOS	ENSP00000465517	ENSP00000261326	chromosome 18 open reading frame 21	molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime	0.646
C18orf21	NABP2	ENSP00000465517	ENSP00000267023	chromosome 18 open reading frame 21	nucleic acid binding protein 2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of d [...]	0.653
C18orf21	RASSF2	ENSP00000465517	ENSP00000368684	chromosome 18 open reading frame 21	Ras association (RalGDS/AF-6) domain family member 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation	0.402
C18orf21	RPRD1A	ENSP00000465517	ENSP00000349955	chromosome 18 open reading frame 21	regulation of nuclear pre-mRNA domain containing 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle	0.659
C18orf21	STK17A	ENSP00000465517	ENSP00000319192	chromosome 18 open reading frame 21	serine/threonine kinase 17a; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species	0.435
C18orf21	STK17B	ENSP00000465517	ENSP00000263955	chromosome 18 open reading frame 21	serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis	0.582
GALNT1	C18orf21	ENSP00000269195	ENSP00000465517	UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7	chromosome 18 open reading frame 21	0.514
ISG20L2	C18orf21	ENSP00000323424	ENSP00000465517	interferon stimulated exonuclease gene 20kDa-like 2; 3’-> 5’-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3’-end containing a free hydroxyl group	chromosome 18 open reading frame 21	0.501
MOCOS	ANKRD52	ENSP00000261326	ENSP00000267116	molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime	ankyrin repeat domain 52; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates	0.462
MOCOS	C18orf21	ENSP00000261326	ENSP00000465517	molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime	chromosome 18 open reading frame 21	0.646

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