PDCD5 protein (Homo sapiens) - STRING network view

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Score

PDCD5

programmed cell death 5; May function in the process of apoptosis (125 aa)

Predicted Functional Partners:

KAT5

0.965

UBC

0.942

TP53

0.924

PFDN5

0.843

FOXP3

0.800

TCEAL1

0.740

GTF2H5

0.656

CSF2

0.610

VHL

0.577

GCNT7

0.576

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF2	FOXP3	ENSP00000296871	ENSP00000365380	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	0.582
CSF2	PDCD5	ENSP00000296871	ENSP00000466214	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	programmed cell death 5; May function in the process of apoptosis	0.610
CSF2	TP53	ENSP00000296871	ENSP00000269305	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.537
FOXP3	CSF2	ENSP00000365380	ENSP00000296871	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	0.582
FOXP3	KAT5	ENSP00000365380	ENSP00000340330	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	K(lysine) acetyltransferase 5	0.961
FOXP3	PDCD5	ENSP00000365380	ENSP00000466214	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	programmed cell death 5; May function in the process of apoptosis	0.800
FOXP3	TP53	ENSP00000365380	ENSP00000269305	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.940
FOXP3	UBC	ENSP00000365380	ENSP00000344818	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	ubiquitin C	0.581
GCNT7	PDCD5	ENSP00000243913	ENSP00000466214	glucosaminyl (N-acetyl) transferase family member 7; Glycosyltransferase (By similarity)	programmed cell death 5; May function in the process of apoptosis	0.576
GTF2H5	PDCD5	ENSP00000415032	ENSP00000466214	general transcription factor IIH, polypeptide 5; Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell	programmed cell death 5; May function in the process of apoptosis	0.656
GTF2H5	UBC	ENSP00000415032	ENSP00000344818	general transcription factor IIH, polypeptide 5; Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell	ubiquitin C	0.620
KAT5	FOXP3	ENSP00000340330	ENSP00000365380	K(lysine) acetyltransferase 5	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	0.961
KAT5	PDCD5	ENSP00000340330	ENSP00000466214	K(lysine) acetyltransferase 5	programmed cell death 5; May function in the process of apoptosis	0.965
KAT5	TP53	ENSP00000340330	ENSP00000269305	K(lysine) acetyltransferase 5	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity)	0.999
KAT5	UBC	ENSP00000340330	ENSP00000344818	K(lysine) acetyltransferase 5	ubiquitin C	0.981
KAT5	VHL	ENSP00000340330	ENSP00000256474	K(lysine) acetyltransferase 5	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2	0.926
PDCD5	CSF2	ENSP00000466214	ENSP00000296871	programmed cell death 5; May function in the process of apoptosis	colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes	0.610
PDCD5	FOXP3	ENSP00000466214	ENSP00000365380	programmed cell death 5; May function in the process of apoptosis	forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response	0.800
PDCD5	GCNT7	ENSP00000466214	ENSP00000243913	programmed cell death 5; May function in the process of apoptosis	glucosaminyl (N-acetyl) transferase family member 7; Glycosyltransferase (By similarity)	0.576
PDCD5	GTF2H5	ENSP00000466214	ENSP00000415032	programmed cell death 5; May function in the process of apoptosis	general transcription factor IIH, polypeptide 5; Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell	0.656

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