node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000254995 | STX10 | ENSP00000457522 | ENSP00000466298 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.988 |
ENSG00000254995 | STX12 | ENSP00000457522 | ENSP00000363054 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) | 0.482 |
ENSG00000254995 | STX5 | ENSP00000457522 | ENSP00000294179 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) | 0.826 |
ENSG00000254995 | STX7 | ENSP00000457522 | ENSP00000356918 | STX16-NPEPL1 readthrough (non-protein coding) | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | 0.495 |
ENSG00000254995 | VAMP4 | ENSP00000457522 | ENSP00000236192 | STX16-NPEPL1 readthrough (non-protein coding) | vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule | 0.958 |
ENSG00000254995 | VTI1A | ENSP00000457522 | ENSP00000376792 | STX16-NPEPL1 readthrough (non-protein coding) | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.988 |
ENSG00000254995 | VTI1B | ENSP00000457522 | ENSP00000450731 | STX16-NPEPL1 readthrough (non-protein coding) | vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence | 0.976 |
ENSG00000254995 | YKT6 | ENSP00000457522 | ENSP00000223369 | STX16-NPEPL1 readthrough (non-protein coding) | YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity | 0.926 |
GCC2 | STX10 | ENSP00000307939 | ENSP00000466298 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | 0.962 |
GCC2 | STX16 | ENSP00000307939 | ENSP00000360183 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | syntaxin 16 | 0.506 |
GCC2 | VAMP4 | ENSP00000307939 | ENSP00000236192 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule | 0.482 |
GCC2 | VTI1A | ENSP00000307939 | ENSP00000376792 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.935 |
STX10 | ENSG00000254995 | ENSP00000466298 | ENSP00000457522 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | STX16-NPEPL1 readthrough (non-protein coding) | 0.988 |
STX10 | GCC2 | ENSP00000466298 | ENSP00000307939 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | 0.962 |
STX10 | STX12 | ENSP00000466298 | ENSP00000363054 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | syntaxin 12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity) | 0.990 |
STX10 | STX16 | ENSP00000466298 | ENSP00000360183 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | syntaxin 16 | 0.984 |
STX10 | STX5 | ENSP00000466298 | ENSP00000294179 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) | 0.969 |
STX10 | STX7 | ENSP00000466298 | ENSP00000356918 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | 0.961 |
STX10 | VAMP4 | ENSP00000466298 | ENSP00000236192 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule | 0.966 |
STX10 | VTI1A | ENSP00000466298 | ENSP00000376792 | syntaxin 10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network | vesicle transport through interaction with t-SNAREs homolog 1A (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with [...] | 0.984 |