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TOX TOX TOX2 TOX2 SF1 SF1 TXNL4B TXNL4B ZNF461 ZNF461 HEATR4 HEATR4 CCDC134 CCDC134 NUDCD1 NUDCD1 HDAC2 HDAC2 FBXO18 FBXO18 NR4A1 NR4A1
"ZNF461" - zinc finger protein 461 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ZNF461zinc finger protein 461; May be involved in transcriptional regulation (563 aa)    
Predicted Functional Partners:
TOX2
TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system (506 aa)
        score_image   score_image   0.955
NR4A1
nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 (611 aa)
        score_image   score_image   0.888
HDAC2
histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] (488 aa)
        score_image   score_image   0.775
HEATR4
HEAT repeat containing 4 (1026 aa)
            score_image   0.673
CCDC134
coiled-coil domain containing 134 (229 aa)
            score_image   0.665
NUDCD1
NudC domain containing 1 (583 aa)
            score_image   0.604
TOX
thymocyte selection-associated high mobility group box; May play a role in regulating T-cell development (By similarity) (526 aa)
        score_image   score_image   0.602
SF1
splicing factor 1 (673 aa)
        score_image       0.576
TXNL4B
thioredoxin-like 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition (149 aa)
            score_image   0.570
FBXO18
F-box protein, helicase, 18 (1094 aa)
      score_image     score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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