Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ENSG00000267001 | Uncharacterized protein (105 aa) | ||||||||||||
Predicted Functional Partners:
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 | SLC39A11 | solute carrier family 39 (metal ion transporter), member 11; May act as a zinc-influx transporter (By similarity) (342 aa) |
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0.711 | |||||||||
 | SLC39A12 | solute carrier family 39 (zinc transporter), member 12 (691 aa) |
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0.524 | |||||||||
 | SLC39A7 | solute carrier family 39 (zinc transporter), member 7 (469 aa) |
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0.524 | |||||||||
 | SLC39A10 | solute carrier family 39 (zinc transporter), member 10; May act as a zinc-influx transporter (831 aa) |
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0.524 | |||||||||
 | SLC39A8 | solute carrier family 39 (zinc transporter), member 8; Acts as a zinc-influx transporter (460 aa) |
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0.524 | |||||||||
 | SLC39A4 | solute carrier family 39 (zinc transporter), member 4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity) (647 aa) |
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0.524 | |||||||||
 | SLC39A14 | solute carrier family 39 (zinc transporter), member 14; May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake (492 aa) |
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0.524 | |||||||||
 | SLC39A6 | solute carrier family 39 (zinc transporter), member 6; May act as a zinc-influx transporter (755 aa) |
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0.524 | |||||||||
 | SLC39A5 | solute carrier family 39 (metal ion transporter), member 5; May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status (By similarity) (540 aa) |
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0.524 | |||||||||
 | SLC30A1 | solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell (507 aa) |
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0.515 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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