ENSG00000267261 protein (Homo sapiens)

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ENSG00000267261

Ras-related protein Rab-5C (282 aa)

Predicted Functional Partners:

ZFYVE20

0.954

RABEP1

0.918

TADA2B

0.914

TADA2A

0.914

KCTD7

0.907

RABGEF1

0.907

PIK3C3

0.904

TAF10

0.896

ZFAND4

0.880

ELP3

0.834

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ELP3	ENSG00000267261	ENSP00000256398	ENSP00000468367	elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration	Ras-related protein Rab-5C	0.834
ENSG00000267261	ELP3	ENSP00000468367	ENSP00000256398	Ras-related protein Rab-5C	elongator acetyltransferase complex subunit 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. Involved in cell migration	0.834
ENSG00000267261	KCTD7	ENSP00000468367	ENSP00000398177	Ras-related protein Rab-5C	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.907
ENSG00000267261	PIK3C3	ENSP00000468367	ENSP00000262039	Ras-related protein Rab-5C	phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes	0.904
ENSG00000267261	RABEP1	ENSP00000468367	ENSP00000262477	Ras-related protein Rab-5C	rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A	0.918
ENSG00000267261	RABGEF1	ENSP00000468367	ENSP00000284957	Ras-related protein Rab-5C	RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.907
ENSG00000267261	TADA2A	ENSP00000468367	ENSP00000225396	Ras-related protein Rab-5C	transcriptional adaptor 2A; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling	0.914
ENSG00000267261	TADA2B	ENSP00000468367	ENSP00000308022	Ras-related protein Rab-5C	transcriptional adaptor 2B; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2	0.914
ENSG00000267261	TAF10	ENSP00000468367	ENSP00000299424	Ras-related protein Rab-5C	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors	0.896
ENSG00000267261	ZFAND4	ENSP00000468367	ENSP00000339484	Ras-related protein Rab-5C	zinc finger, AN1-type domain 4	0.880
ENSG00000267261	ZFYVE20	ENSP00000468367	ENSP00000253699	Ras-related protein Rab-5C	zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3)	0.954
KCTD7	ENSG00000267261	ENSP00000398177	ENSP00000468367	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	Ras-related protein Rab-5C	0.907
KCTD7	PIK3C3	ENSP00000398177	ENSP00000262039	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes	0.578
KCTD7	RABEP1	ENSP00000398177	ENSP00000262477	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A	0.997
KCTD7	RABGEF1	ENSP00000398177	ENSP00000284957	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	RAB guanine nucleotide exchange factor (GEF) 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.916
KCTD7	ZFAND4	ENSP00000398177	ENSP00000339484	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	zinc finger, AN1-type domain 4	0.510
KCTD7	ZFYVE20	ENSP00000398177	ENSP00000253699	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3)	0.800
PIK3C3	ENSG00000267261	ENSP00000262039	ENSP00000468367	phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes	Ras-related protein Rab-5C	0.904
PIK3C3	KCTD7	ENSP00000262039	ENSP00000398177	phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes	potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity)	0.578
PIK3C3	RABEP1	ENSP00000262039	ENSP00000262477	phosphatidylinositol 3-kinase, catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes	rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A	0.459

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