ENSG00000266953 protein (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

ENSG00000266953

Uncharacterized protein (209 aa)

Predicted Functional Partners:

TPI1

0.964

PGK1

0.956

PGK2

0.956

PGM5

0.923

PGM1

0.923

PFKP

0.911

PFKM

0.911

PFKL

0.911

ENO4

0.886

ENO3

0.886

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENO3	ENO4	ENSP00000324105	ENSP00000345555	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	enolase family member 4	0.522
ENO3	ENSG00000266953	ENSP00000324105	ENSP00000468690	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	Uncharacterized protein	0.886
ENO3	PFKL	ENSP00000324105	ENSP00000269848	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.934
ENO3	PFKM	ENSP00000324105	ENSP00000345771	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.941
ENO3	PFKP	ENSP00000324105	ENSP00000370517	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.929
ENO3	PGK1	ENSP00000324105	ENSP00000362413	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.986
ENO3	PGK2	ENSP00000324105	ENSP00000305995	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphoglycerate kinase 2	0.986
ENO3	PGM1	ENSP00000324105	ENSP00000360124	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphoglucomutase 1	0.879
ENO3	PGM5	ENSP00000324105	ENSP00000379678	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	phosphoglucomutase 5	0.777
ENO3	TPI1	ENSP00000324105	ENSP00000229270	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	triosephosphate isomerase 1	0.985
ENO4	ENO3	ENSP00000345555	ENSP00000324105	enolase family member 4	enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration	0.522
ENO4	ENSG00000266953	ENSP00000345555	ENSP00000468690	enolase family member 4	Uncharacterized protein	0.886
ENO4	PFKL	ENSP00000345555	ENSP00000269848	enolase family member 4	phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.893
ENO4	PFKM	ENSP00000345555	ENSP00000345771	enolase family member 4	phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.897
ENO4	PFKP	ENSP00000345555	ENSP00000370517	enolase family member 4	phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.893
ENO4	PGK1	ENSP00000345555	ENSP00000362413	enolase family member 4	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.985
ENO4	PGK2	ENSP00000345555	ENSP00000305995	enolase family member 4	phosphoglycerate kinase 2	0.983
ENO4	PGM1	ENSP00000345555	ENSP00000360124	enolase family member 4	phosphoglucomutase 1	0.777
ENO4	PGM5	ENSP00000345555	ENSP00000379678	enolase family member 4	phosphoglucomutase 5	0.777
ENO4	TPI1	ENSP00000345555	ENSP00000229270	enolase family member 4	triosephosphate isomerase 1	0.978

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