ENSG00000171570 protein (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSG00000171570

RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (213 aa)

Predicted Functional Partners:

CIITA

0.853

STX4

0.740

STX2

0.721

STX11

0.721

STX3

0.721

STX19

0.721

STX1A

0.721

STX1B

0.721

AGFG1

0.667

AP1G2

0.563

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGFG1	ENSG00000171570	ENSP00000387282	ENSP00000469872	ArfGAP with FG repeats 1	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	0.667
AP1G2	ENSG00000171570	ENSP00000312442	ENSP00000469872	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	0.563
AP1G2	STX11	ENSP00000312442	ENSP00000356540	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network	0.489
AP1G2	STX19	ENSP00000312442	ENSP00000320679	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 19	0.489
AP1G2	STX1A	ENSP00000312442	ENSP00000222812	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 1A (brain)	0.489
AP1G2	STX1B	ENSP00000312442	ENSP00000215095	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.489
AP1G2	STX2	ENSP00000312442	ENSP00000376178	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.489
AP1G2	STX3	ENSP00000312442	ENSP00000338562	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.505
AP1G2	STX4	ENSP00000312442	ENSP00000317714	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.489
CIITA	ENSG00000171570	ENSP00000316328	ENSP00000469872	class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	0.853
ENSG00000171570	AGFG1	ENSP00000469872	ENSP00000387282	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	ArfGAP with FG repeats 1	0.667
ENSG00000171570	AP1G2	ENSP00000469872	ENSP00000312442	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	adaptor-related protein complex 1, gamma 2 subunit; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV)	0.563
ENSG00000171570	CIITA	ENSP00000469872	ENSP00000316328	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter	0.853
ENSG00000171570	STX11	ENSP00000469872	ENSP00000356540	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network	0.721
ENSG00000171570	STX19	ENSP00000469872	ENSP00000320679	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 19	0.721
ENSG00000171570	STX1A	ENSP00000469872	ENSP00000222812	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 1A (brain)	0.721
ENSG00000171570	STX1B	ENSP00000469872	ENSP00000215095	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.721
ENSG00000171570	STX2	ENSP00000469872	ENSP00000376178	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.721
ENSG00000171570	STX3	ENSP00000469872	ENSP00000338562	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.721
ENSG00000171570	STX4	ENSP00000469872	ENSP00000317714	RAB4B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity)	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.740

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About