node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBXL19 | GZF1 | ENSP00000369666 | ENSP00000338290 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | GDNF-inducible zinc finger protein 1 | 0.501 |
FBXL19 | ZNF335 | ENSP00000369666 | ENSP00000325326 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 335; Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6 | 0.501 |
FBXL19 | ZSCAN18 | ENSP00000369666 | ENSP00000470123 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.501 |
GZF1 | FBXL19 | ENSP00000338290 | ENSP00000369666 | GDNF-inducible zinc finger protein 1 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
GZF1 | KDM2A | ENSP00000338290 | ENSP00000432786 | GDNF-inducible zinc finger protein 1 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
GZF1 | KDM2B | ENSP00000338290 | ENSP00000366271 | GDNF-inducible zinc finger protein 1 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
GZF1 | LRRC66 | ENSP00000338290 | ENSP00000341944 | GDNF-inducible zinc finger protein 1 | leucine rich repeat containing 66 | 0.592 |
GZF1 | PTPN23 | ENSP00000338290 | ENSP00000265562 | GDNF-inducible zinc finger protein 1 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |
GZF1 | XRN1 | ENSP00000338290 | ENSP00000264951 | GDNF-inducible zinc finger protein 1 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.543 |
GZF1 | ZFAND4 | ENSP00000338290 | ENSP00000339484 | GDNF-inducible zinc finger protein 1 | zinc finger, AN1-type domain 4 | 0.416 |
GZF1 | ZSCAN18 | ENSP00000338290 | ENSP00000470123 | GDNF-inducible zinc finger protein 1 | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.524 |
KDM2A | GZF1 | ENSP00000432786 | ENSP00000338290 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | GDNF-inducible zinc finger protein 1 | 0.501 |
KDM2A | ZNF335 | ENSP00000432786 | ENSP00000325326 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 335; Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6 | 0.501 |
KDM2A | ZSCAN18 | ENSP00000432786 | ENSP00000470123 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.501 |
KDM2B | GZF1 | ENSP00000366271 | ENSP00000338290 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | GDNF-inducible zinc finger protein 1 | 0.501 |
KDM2B | ZNF335 | ENSP00000366271 | ENSP00000325326 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 335; Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6 | 0.501 |
KDM2B | ZSCAN18 | ENSP00000366271 | ENSP00000470123 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation | 0.501 |
LRRC66 | GZF1 | ENSP00000341944 | ENSP00000338290 | leucine rich repeat containing 66 | GDNF-inducible zinc finger protein 1 | 0.592 |
LRRC66 | ZFAND4 | ENSP00000341944 | ENSP00000339484 | leucine rich repeat containing 66 | zinc finger, AN1-type domain 4 | 0.636 |
LRRC66 | ZNF335 | ENSP00000341944 | ENSP00000325326 | leucine rich repeat containing 66 | zinc finger protein 335; Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6 | 0.715 |