STRING 9.05 
RELA [ENSP00000384273]
 
v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the ind [...]
NFKBIA [ENSP00000216797]
 
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:   yes (score 0.006).  
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:   none, but putative homologs are coexpressed in other species (score 0.060).  
Experimental/Biochemical Data:   yes (score 0.999). In addition, putative homologs were found interacting in other species (score 0.310).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.947).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Reaction:yes (score: 0.900)  
Binding:yes (score: 0.999)