pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex
dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes
Evidence suggesting a functional link:
Neighborhood in the Genome:
None, but homologous genes are neighbors in other genomes (score 0.736).
yes (score 0.068).
Cooccurence Across Genomes:
yes (score 0.319).
yes (score 0.271). In addition, putative homologs are coexpressed in other species (score 0.411).
yes (score 0.983). In addition, putative homologs were found interacting in other species (score 0.243).
Association in Curated Databases:
yes (score 0.900).
Co-Mentioned in PubMed Abstracts:
yes (score 0.896). In addition, putative homologs are mentioned together in other species (score 0.639).