pyruvate dehydrogenase (lipoamide) beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
pyruvate dehydrogenase complex, component X; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex
Evidence suggesting a functional link:
Neighborhood in the Genome:
None, but homologous genes are neighbors in other genomes (score 0.792).
yes (score 0.015).
Cooccurence Across Genomes:
yes (score 0.370).
yes (score 0.279). In addition, putative homologs are coexpressed in other species (score 0.343).
yes (score 0.621). In addition, putative homologs were found interacting in other species (score 0.240).
Association in Curated Databases:
yes (score 0.900).
Co-Mentioned in PubMed Abstracts:
yes (score 0.796). In addition, putative homologs are mentioned together in other species (score 0.615).