STRING 9.05 
MSH6 [ENSP00000234420]
 
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resyn [...]
MLH1 [ENSP00000231790]
 
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...]
Evidence suggesting a functional link:
Neighborhood in the Genome:   None, but homologous genes are neighbors in other genomes (score 0.076).  
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:   yes (score 0.471).  
Co-Expression:   none, but putative homologs are coexpressed in other species (score 0.252).  
Experimental/Biochemical Data:   yes (score 0.729). In addition, putative homologs were found interacting in other species (score 0.306).  
Association in Curated Databases:   yes (score 0.540).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.978). In addition, putative homologs are mentioned together in other species (score 0.071).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Binding:yes (score: 0.981)