STRING 9.05 
SLC12A3 [ENSP00000262502]
 
solute carrier family 12 (sodium/chloride transporters), member 3; Electrically silent transporter system. Mediates sodium and chloride reabsorption
WNK4 [ENSP00000246914]
 
WNK lysine deficient protein kinase 4; Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity)
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.621).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.774). In addition, putative homologs are mentioned together in other species (score 0.144).  
Combined Score:
 
0.916
 
Evidence for specific actions:
Expression:yes (score: 0.181)