STRING 9.05 
DACH1 [ENSP00000352712]
 
dachshund homolog 1 (Drosophila); Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin- dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through [...]
SIX1 [ENSP00000247182]
 
SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity)
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.621). In addition, putative homologs were found interacting in other species (score 0.131).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.940).  
Combined Score:
 
0.977
 
Evidence for specific actions:
Expression with Inhibition:yes (score: 0.800)