STRING 9.05 
IL1B [ENSP00000263341]
 
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells
IL1RAP [ENSP00000072516]
 
interleukin 1 receptor accessory protein; Mediates interleukin-1-dependent activation of NF-kappa- B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.983).  
Association in Curated Databases:   yes (score 0.800).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.241).  
Combined Score:
 
0.997
 
Evidence for specific actions:
Binding:yes (score: 0.989)