STRING 9.05 
MDM2 [ENSP00000417281]
 
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
PML [ENSP00000268058]
 
promyelocytic leukemia; Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies. Inhibits specifically the activity of the tetrameric form of PKM2. May play a role in glycolytic metabolism by modulating the activity of PKM2. Together with SATB1, involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.995).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.349).  
Combined Score:
 
0.997
 
Evidence for specific actions:
Binding:yes (score: 0.989)