STRING 9.05 
MDM2 [ENSP00000417281]
 
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Functions as an ubiquitin ligase E3 toward ARRB1 (By similarity)
AKT1 [ENSP00000270202]
 
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protei [...]
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.999).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.925).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Catalysis:yes (score: 0.900)  
Post-translational modification:yes (score: 0.800)  
Binding:yes (score: 0.937)