STRING 9.05 
CD28 [ENSP00000324890]
 
CD28 molecule; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival
PIK3R1 [ENSP00000274335]
 
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.999).  
Association in Curated Databases:   yes (score 0.800).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.268).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Binding:yes (score: 0.999)