STRING 9.05 
PAX6 [ENSP00000368401]
 
paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes
EN1 [ENSP00000295206]
 
engrailed homeobox 1
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.620).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.340).  
Combined Score:
 
0.669
 
Note: the two proteins have some sequence similarity (61.2 bits over 66 amino acids. click here to see the alignment).
Evidence for specific actions:
Binding:yes (score: 0.620)