STRING 9.05 
LEPR [ENSP00000330393]
leptin receptor; Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity)
LEP [ENSP00000312652]
leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
Gene Fusions:  
none / insignificant.
Cooccurence Across Genomes:  
none / insignificant.
none / insignificant.
Experimental/Biochemical Data:   yes (score 0.846). In addition, putative homologs were found interacting in other species (score 0.377).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.982).  
Combined Score:
Evidence for specific actions:
Binding:yes (score: 0.989)  
Activation:yes (score: 0.800)  
Expression with Inhibition:yes (score: 0.800)  
Post-translational modification:yes (score: 0.581)