STRING 9.05 
PRF1 [ENSP00000316746]
 
perforin 1 (pore forming protein); In the presence of calcium, binds to target cell membranes. Inserts into target cell membranes and forms pores, and so contributes to cytolysis and apoptosis of target cells
GZMB [ENSP00000216341]
 
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:   yes (score 0.643).  
Experimental/Biochemical Data:   yes (score 0.846).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.900).  
Combined Score:
 
0.999