STRING 9.05 
BCL2 [ENSP00000329623]
 
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
TP53 [ENSP00000269305]
 
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.974).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.953).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Binding:yes (score: 0.984)  
Reaction:yes (score: 0.900)  
Expression with Inhibition:yes (score: 0.800)