STRING 9.05 
PKLR [ENSP00000339933]
 
pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity)
PKM2 [ENSP00000320171]
 
pyruvate kinase, muscle; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferat [...]
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:   yes (score 0.525).  
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   none, but putative homologs were found interacting in other species (score 0.215).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.859). In addition, putative homologs are mentioned together in other species (score 0.234).  
Combined Score:
 
0.256
 
Note: the two proteins have some sequence similarity (869 bits over 523 amino acids. click here to see the alignment).
Evidence for specific actions:
Binding:yes (score: 0.823)