STRING 9.05 
TRIM33 [ENSP00000351250]
 
tripartite motif-containing 33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as a [...]
SMAD4 [ENSP00000341551]
 
SMAD family member 4; Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:   yes (score 0.173).  
Experimental/Biochemical Data:   yes (score 0.965).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.427). In addition, putative homologs are mentioned together in other species (score 0.144).  
Combined Score:
 
0.998
 
Evidence for specific actions:
Binding:yes (score: 0.962)  
Reaction:yes (score: 0.900)  
Catalysis:yes (score: 0.900)  
Post-translational modification:yes (score: 0.181)