STRING 9.05 
NR3C2 [ENSP00000350815]
nuclear receptor subfamily 3, group C, member 2; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels
PIAS1 [ENSP00000249636]
protein inhibitor of activated STAT, 1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
Gene Fusions:  
none / insignificant.
Cooccurence Across Genomes:  
none / insignificant.
none / insignificant.
Experimental/Biochemical Data:   yes (score 0.621).  
Association in Curated Databases:  
none / insignificant.
Co-Mentioned in PubMed Abstracts:   yes (score 0.105).  
Combined Score:
Evidence for specific actions:
Binding:yes (score: 0.621)