STRING 9.05 
NTRK1 [ENSP00000351486]
 
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway
PIK3R1 [ENSP00000274335]
 
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.846).  
Association in Curated Databases:   yes (score 0.800).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.065).  
Combined Score:
 
0.967
 
Evidence for specific actions:
Binding:yes (score: 0.621)