STRING 9.05 
RYR2 [ENSP00000355533]
 
ryanodine receptor 2 (cardiac); Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T- tubules (By similarity)
CACNA1C [ENSP00000266376]
 
calcium channel, voltage-dependent, L type, alpha 1C subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and b [...]
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.621).  
Association in Curated Databases:   yes (score 0.720).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.426).  
Combined Score:
 
0.930
 
Evidence for specific actions:
Binding:yes (score: 0.893)