STRING 9.05 
DPYD [ENSP00000359211]
 
dihydropyrimidine dehydrogenase; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil
DPYS [ENSP00000276651]
 
dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyzes the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate
Evidence suggesting a functional link:
Neighborhood in the Genome:   None, but homologous genes are neighbors in other genomes (score 0.293).  
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:  
none / insignificant.
    
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.790). In addition, putative homologs are mentioned together in other species (score 0.048).  
Combined Score:
 
0.983