STRING 9.05 
HPSE2 [ENSP00000359583]
 
heparanase 2; Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies
SDC1 [ENSP00000254351]
 
syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:  
none / insignificant.
    
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.284). In addition, putative homologs are mentioned together in other species (score 0.073).  
Combined Score:
 
0.924
 
Evidence for specific actions:
Catalysis:yes (score: 0.900)