STRING 9.05 
HPSE2 [ENSP00000359583]
 
heparanase 2; Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Also implicated in the extravasation of leukocytes and tumor cell lines. Due to its contribution to metastasis and angiogenesis, it is considered to be a potential target for anti- cancer therapies
GPC1 [ENSP00000264039]
 
glypican 1; Cell surface proteoglycan that bears heparan sulfate (By similarity)
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:  
none / insignificant.
    
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.083).  
Combined Score:
 
0.902
 
Evidence for specific actions:
Catalysis:yes (score: 0.900)