STRING 9.05 
CD40 [ENSP00000361359]
CD40 molecule, TNF receptor superfamily member 5; Receptor for TNFSF5/CD40LG
TRAF3 [ENSP00000332468]
TNF receptor-associated factor 3; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Seems to be involved in activation of NF- kappa-B and JNK and in apoptosis. Is regulated by TANK/ITRAF which competes with TNFRSF5/CD40 for binding. Seems to play a role T- cell dependent immune responses
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
Gene Fusions:  
none / insignificant.
Cooccurence Across Genomes:  
none / insignificant.
none / insignificant.
Experimental/Biochemical Data:   yes (score 0.998). In addition, putative homologs were found interacting in other species (score 0.180).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.929).  
Combined Score:
Evidence for specific actions:
Binding:yes (score: 0.999)