| CHEK2 [ENSP00000372023]|
CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'
|↔|| PRRX2 [ENSP00000361547]|
paired related homeobox 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development