STRING 9.05 
WAS [ENSP00000365891]
 
Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Effector protein for Rho-type GTPases, providing a link with the Arp2/3 complex that regulates the structure and dynamics of the actin cytoskeleton. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function
WIPF1 [ENSP00000352802]
 
WAS/WASL interacting protein family, member 1; May have direct activity on the actin cytoskeleton. Induces actin polymerization and redistribution. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.996). In addition, putative homologs were found interacting in other species (score 0.128).  
Association in Curated Databases:  
none / insignificant.
    
Co-Mentioned in PubMed Abstracts:   yes (score 0.927).  
Combined Score:
 
0.999
 
Evidence for specific actions:
Binding:yes (score: 0.987)