STRING 9.05 
ITM2B [ENSP00000367828]
 
integral membrane protein 2B
APP [ENSP00000284981]
 
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6)
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:  
none / insignificant.
    
Experimental/Biochemical Data:   yes (score 0.621). In addition, putative homologs were found interacting in other species (score 0.084).  
Association in Curated Databases:   yes (score 0.900).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.865).  
Combined Score:
 
0.994
 
Evidence for specific actions:
Binding:yes (score: 0.821)  
Reaction:yes (score: 0.900)