STRING 9.05 
PMS1 [ENSP00000406490]
 
PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA
MLH1 [ENSP00000231790]
 
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...]
Evidence suggesting a functional link:
Neighborhood in the Genome:  
none / insignificant.
    
Gene Fusions:  
none / insignificant.
    
Cooccurence Across Genomes:  
none / insignificant.
    
Co-Expression:   none, but putative homologs are coexpressed in other species (score 0.072).  
Experimental/Biochemical Data:   yes (score 0.954).  
Association in Curated Databases:   yes (score 0.540).  
Co-Mentioned in PubMed Abstracts:   yes (score 0.971).  
Combined Score:
 
0.985
 
Note: the two proteins have some sequence similarity (156.5 bits over 674 amino acids. click here to see the alignment).
Evidence for specific actions:
Binding:yes (score: 0.997)