STRING 9.05 
  NFKBIA protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription (317 aa)
(Homo sapiens)
Predicted Functional Partners:
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Acts as part of the [...] (756 aa)
     0.999
RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian); NF-kappa-B is a pleiotropic trans [...] (551 aa)
    0.999
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Regulatory subunit [...] (487 aa)
     0.999
NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotrop [...] (969 aa)
   0.999
BTRC
beta-transducin repeat containing; Substrate recognition component of a SCF (SKP1-CUL1-F- box p [...] (605 aa)
     0.999
CHUK
conserved helix-loop-helix ubiquitous kinase; Acts as part of the IKK complex in the convention [...] (745 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
FBXW11
F-box and WD repeat domain containing 11; Substrate recognition component of a SCF (SKP1-CUL1-F [...] (542 aa)
     0.997
CUL1
cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiqui [...] (776 aa)
      0.996
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) u [...] (163 aa)
      0.995
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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