STRING 9.05 
  COMP protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
COMP
cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (757 aa)
(Homo sapiens)
Predicted Functional Partners:
MATN1
matrilin 1, cartilage matrix protein; Cartilage matrix protein is a major component of the extr [...] (496 aa)
       0.877
SOX9
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal developmen [...] (509 aa)
       0.867
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
       0.830
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alph [...] (1039 aa)
      0.828
ITGA11
integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen (1188 aa)
      0.812
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a rece [...] (1181 aa)
      0.812
CD36
CD36 molecule (thrombospondin receptor); Seems to have numerous potential physiological functio [...] (472 aa)
      0.808
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
       0.808
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a recep [...] (788 aa)
     0.807
CD47
CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on [...] (323 aa)
      0.804
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (22%)
Permalink