STRING 9.05 
  COMP protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] (757 aa)
(Homo sapiens)
Predicted Functional Partners:
matrilin 1, cartilage matrix protein; Cartilage matrix protein is a major component of the extr [...] (496 aa)
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal developmen [...] (509 aa)
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alph [...] (1039 aa)
integrin, alpha 11; Integrin alpha-11/beta-1 is a receptor for collagen (1188 aa)
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a rece [...] (1181 aa)
CD36 molecule (thrombospondin receptor); Seems to have numerous potential physiological functio [...] (472 aa)
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a recep [...] (788 aa)
CD47 molecule; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on [...] (323 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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additional (white) nodes

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