STRING 9.05 
  GCK protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
GCK
glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
(Homo sapiens)
Predicted Functional Partners:
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
      0.986
GCKR
glucokinase (hexokinase 4) regulator; Inhibits glucokinase by forming an inactive complex with [...] (625 aa)
      0.983
PKM2
pyruvate kinase, muscle; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group fr [...] (531 aa)
    0.967
PKLR
pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) (574 aa)
     0.966
GPI
glucose phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can functi [...] (558 aa)
     0.962
PGM1
phosphoglucomutase 1; This enzyme participates in both the breakdown and synthesis of glucose (562 aa)
     0.932
LCT
lactase; LPH splits lactose in the small intestine (1927 aa)
      0.913
PGM2
phosphoglucomutase 2; This enzyme participates in both the breakdown and synthesis of glucose ( [...] (612 aa)
      0.904
SREBF1
sterol regulatory element binding transcription factor 1; Transcriptional activator required fo [...] (1177 aa)
      0.902
GLB1
galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glyc [...] (677 aa)
      0.902
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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