STRING 9.05 
  APOA5 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
APOA5
apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin-cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (366 aa)
(Homo sapiens)
Predicted Functional Partners:
PPARA
peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key re [...] (468 aa)
      0.988
APOC3
apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake o [...] (99 aa)
     0.986
APOC2
apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, a [...] (101 aa)
     0.971
APOB
apolipoprotein B (including Ag(x) antigen); Apolipoprotein B is a major protein constituent of [...] (4563 aa)
     0.968
APOA2
apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association [...] (100 aa)
     0.964
APOA1
apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the li [...] (267 aa)
    0.944
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particle [...] (317 aa)
     0.922
APOA4
apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Require [...] (396 aa)
    0.921
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
      0.908
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1; F-box-like protein involved in the recruitment of [...] (514 aa)
       0.899
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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