STRING 9.05 
  CDKN1B protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events (198 aa)
(Homo sapiens)
Predicted Functional Partners:
CDK2
cyclin-dependent kinase 2; Involved in the control of the cell cycle. Interacts with cyclins A, [...] (298 aa)
     0.999
CDK4
cyclin-dependent kinase 4; Probably involved in the control of the cell cycle (303 aa)
     0.999
CCND1
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition (295 aa)
     0.999
CCND3
cyclin D3; Essential for the control of the cell cycle at the G1/S (start) transition. Potentia [...] (292 aa)
     0.999
SKP2
S-phase kinase-associated protein 2 (p45); Substrate recognition component of a SCF (SKP1-CUL1- [...] (424 aa)
     0.999
CCNE1
cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa)
     0.999
UBC
ubiquitin C (685 aa)
     0.999
CCNA2
cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosi [...] (432 aa)
     0.999
CDK6
cyclin-dependent kinase 6; Probably involved in the control of the cell cycle. Interacts with D [...] (326 aa)
     0.999
COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit o [...] (334 aa)
      0.999
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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